Days Set Up
Monday - Friday
Analytic Time

21 - 28 days

MiChart Code
NOGGIN Gene Sequencing
Soft Order Code
NOGS

Test Updated:

Synonyms

NOGS
NOGGIN Gene Sequencing (NOG)
NOGSS
NOGGIN Gene Sequencing Shadow
NOG Gene Sequencing
Proximal Symphalangism
Multiple Synostoses Syndrome 1
Tarsal-Carpal Coalition Syndrome
Stapes Ankylosis without Symphalangism
Berachydactyly Type B2
Tarsal Carpal Coalition Syndrome

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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

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Test Overview

Test Methodology

NOG (exonic and intronic splice site consensus) sequences are amplfied using specific primers and bidirectionally sequenced using a fluorescent method.

Test Usage

Confirmation of a diagnosis of Proximal Symphalangism (SYM1, OMIM # 185800) or Multiple Synostoses Syndrome 1 (SYNS1, OMIM #186500). NOG mutation analysis is also useful in the diagnosis of Tarsal-Carpal Coalition Syndrome (OMIM #186570), Stapes Ankylosis with broad thumbs and toes and without Symphalangism (OMIM #184460), and Brachydactyly Type B2 (BDB2, OMIM #611377).

Reference Range

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a lavender top tube. Send intact specimen within 24 hours if stored at room temperature or within 5 days if stored refrigerated. Include the patient's family history, pedigree, and ethnicity on the test requisition. Obtaining informed consent from the patient prior to genetic testing is strongly recommended. If desired, a UMHS Request and Consent for Genetic Testing form can be obtained from the MMGL Molecular Genetics Laboratory by contacting the MLabs Client Services Center at 800-862-7284 or online at https://mlabs.umich.edu/sites/default/files/2020-01/file/pci-mmgl_infor…

Lavender Top Tube
Normal Volume
5 - 10 mL EDTA whole blood
Minimum Volume
2 mL EDTA whole blood

Billing Information

CPT Code
81403
Pro Fee Code
 
LOINC
 

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.