Test Overview
Test Methodology

Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)

Test Usage

Diagnosis of nickel poisoning.

Reference Range *

0-17 yrs: not established; >or=18 yrs: <6.0 mcg/24h

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Nickel exists in the environment at 1,000 times the concentration found in biological specimens. Specimen collection procedures require rigorous attention to ultraclean specimen collection procedures, tubes, sample handling and analysis. Hypernickelemia in the absence of exposure to Ni(CO)4 - nickel carbonyl - may be an incidental finding or due to contamination.

Test Details
Days Set Up
Analytic Time

2 - 9 days

Soft Order Code
MiChart Code
Nickel, 24 HR Urine (Sendout)
  • NI-U
  • Ni (Nickel), Urine
Reference Laboratory
Mayo NIU (8626)
Special Testing
Specimen Requirements
Collection Instructions

Collect 24 hour urine in a clean, plastic container with no metal cap or glued insert and no preservative. Aliquot urine into a clean, plastic container with no metal cap or glued insert and refrigerate within 4 hours of completion of collection. Record 24 hour urine volume and collection dates/times on the request form. Collection must take place prior to or 48 hours after administering gadolinium-containing contrast media.

Investigation of hypernickelemia should be limited to patients with potential for exposure to Ni(CO)4 - nickel carbonyl - used in petroleum refining and in the plastics industry. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Normal Volume
10 mL aliquot of 24 hour urine collection
Minimum Volume
1 mL aliquot of 24 hour urine collection
Additional Information

Test sent to Mayo Medical Laboratories.

CPT Code
Fee Code