Test Overview
Test Methodology

Fluorescence Activated Cell Sorting (FACS) Assay

Test Usage

Establishing the diagnosis of neuromyelitis optica (NMO) and related disorders (e.g., relapsing transverse myelitis or relapsing optic neuritis) and distinguishing these disorders from multiple sclerosis early in the course of the disease.

Reference Range *

Negative

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

A negative result does not exclude a diagnosis of neuromyelitis optica spectrum disorder (NMOSD). Serum is generally more sensitive than cerebrospinal fluid for detection of neuromyelitis optica (NMO)/aquaporin-4(AQP4)-IgG (NMO-IgG/AQP4-IgG.

Test Details
Days Set Up
Monday, Tuesday, Thursday
Analytic Time

4 - 7 days

Soft Order Code
NMOFC
MiChart Code
NMO/AQP4-IgG CBA, CSF (Sendout)
Synonyms
  • NMO/AQP4 IgG CBA
  • NMOCC
  • Devic's Disease Antibody
  • NMO Autoantibody
  • Aquaporin
  • Opic Neuritis Antibody
  • Transverse Myelitis Antibody
Laboratory
Sendout
Reference Laboratory
Mayo NMOFC
Section
Special Testing
Test Updated
04/28/2021
Update Type
Test Down or Delayed
Specimen Requirements
Collection Instructions

Collect CSF specimen and refrigerate. Include relevant clinical information as well as ordering physician name, telephone number, and mailing address.

Normal Volume
3 mL CSF
Minimum Volume
2 mL CSF
Additional Information

If results require further evaluation, Neuromyelitis Optica (NMO) / Aquaporin-4-IgG, CSF, Titer will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.

Billing
CPT Code
86255
Fee Code
38139
Reflex CPT
86256
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