Update Type: Test Resumed
Test Updated: 05/26/2021
Test Overview
Test Methodology

Real time quantitative polymerase chain reaction (RT-qPCR)

Test Usage

Adjunct to serum prostate specific antigen (PSA) for risk stratification of patients undergoing prostate biopsy. The LynxDx MyProstateScore™ (MPS) test incorporates serum PSA, urine PCA3 score, and urine TMPRSS2: ERG score in logistic regression models to derive scores giving the risk of detecting high grade (Gleason score >7) prostate cancer on diagnostic needle biopsy.

Reference Range *

The TMPRSS2: ERG score ranges from 0 to 100, with higher scores associated with an increased risk of high grade cancer on diagnostic biopsy. The LynxDx MyProstateScore™ (MPS) report provides a high grade prostate cancer risk score, indicating the risk of high grade prostate cancer (Gleason score >7) on diagnostic needle biopsy.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Analytic Time

typically 3 - 5 days

Soft Order Code
MiChart Code
MyProstateScore (MPS) 2.0
  • MIPS
  • T2ERG
  • T2:ERG
  • PCA3
  • Prostate Cancer Risk Assessment
  • MPS (MyProstateScore)
  • MIPS
Special Testing
Specimen Requirements

Specimen Collection

1. Perform an attentive DRE immediately prior to specimen collection (the specimen should be collected within approximately 1 hour of DRE):
[list order=Y type=a]
Apply firm pressure from the base to the apex and from the lateral to the medial line of the prostate.
Apply enough pressure to depress the surface slightly.
Perform 3 strokes for each lobe.
[/list]2. Instruct patient to collect the FIRST 20 - 30 mL of voided urine (do not catheterize) following the DRE.
3. Process the specimen within 4 hours of collection (if specimen cannot be processed within 15 minutes, store refrigerated or on ice and process within 4 hours).

Specimen Processing

1. Invert specimen cup 5 times to re-suspend cells.
2. Add 2.3 mL of urine to each of two GEN-PROBE PROGENSA PCA3 Urine Specimen Transport Tubes. Do not puncture the foil seal on the cap of the Transport Tube. The specimen volume must fall between the two black fill lines on the Transport Tube.
3. Tightly re-cap each Urine Transport Tube and gently invert 5 times to mix; do not shake or vortex. The specimen is now a "processed" urine specimen. Specimens must be received by performing laboratory within 5 days of collection. Shipping materials will be provided to return the specimen.
4. Label the Transport Tube with the patient’s first and last names as well as a second identifier such as the patient’s date of birth or medical record number.
5. Include serum PSA result and patient history with the specimens.

Special Handling

Attentive DRE must be performed immediately prior to specimen collection. Specimen must be processed within 4 hours of collection. Please refer to Collection Instructions for additional details.

Normal Volume
30 mL urine
Minimum Volume
5 mL urine
Storage Temperature
Room temperature (ambient): 5 days, Refrigerated: 14 days, Frozen: 90 days.
Additional Information

Contact LynxDx for ordering information: https://www.myprostatescore.com. Ordering clinician must provide serum PSA level (ng/mL) for a MyProstateScore report to be generated.

CPT Code
NY State Approved