Test Overview
Test Methodology


Test Usage

The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups.
The first group is found only in patients with myositis and is known as Myositis Specific Autoantibodies (MSA). The MSAs have been shown to be highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, necrotizing myositis and overlap syndromes.
The second group of antibodies is considered Myositis Associated Autoantibodies (MAA) and can be found in patients with overlap syndromes such as polymyositis/scleroderma. MAA can also be found in non-overlap syndromes.

Test Details
Analytic Time

14 - 21 days

Soft Order Code
MiChart Code
Myomarker 3 Panel
  • Jo-1 Antibody
  • Mi-2 Antibody
  • PL-12 Antibody
  • PL-7 Antibody
  • EJ Antibody
  • OJ Antibody
  • SRP Antibody
  • Ku Antibody
  • U2 RNP Antibody
  • PM-Scl Antibody
  • MDA5 Antibody
  • NXP2 Antibody
  • TIF1 Antibody
  • SSA-52 kd IgG Antibody
  • U1 RNP Antibody
  • Fibrillarin U3 RNP Antibody
  • Myositis Specific Antibodies (MSA)
Reference Laboratory
Labcorp (Esoterix # 520080)
Special Testing
Specimen Requirements

Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. EDTA plasma is also acceptable.

Special Handling

This test is restricted to Neurology and Rheumatology OUTPATIENTs only per Lab Formulary Committee. If requested by another service, they need to contact Dr Jeffrey Warren, Medical Director of Sendouts for permission. And the test will need to be ordered as a Miscellaneous Sendout in MiChart if approved.

Yellow Top Tube
Normal Volume
3 mL serum
Additional Information

Panel includes Jo-1, Mi-2, PL-12, PL-7, EJ, OJ, SRP, Ku, U2 RNP, PM-Scl, MDA5, NXP2, TIF1, SSA 52 kD IgG, U1 RNP, and Fibrillarin U3 RNP. Test sent to Labcorp Dublin; performed by Esoterix Endocrinology

CPT Code
83516 x9, 86235 x7
Fee Code
AA303 x9, AA305 x7
NY State Approved