Test Overview
RIPA, EIA
The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical utilities that fall into two main groups.
The first group is found only in patients with myositis and is known as Myositis Specific Autoantibodies (MSA). The MSAs have been shown to be highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, necrotizing myositis and overlap syndromes.
The second group of antibodies is considered Myositis Associated Autoantibodies (MAA) and can be found in patients with overlap syndromes such as polymyositis/scleroderma. MAA can also be found in non-overlap syndromes.
Interpretive report provided
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Test Details
25 days
- Jo-1 Antibody
- Mi-2 Antibody
- PL-12 Antibody
- PL-7 Antibody
- EJ Antibody
- OJ Antibody
- SRP Antibody
- Ku Antibody
- U2 RNP Antibody
- PM-Scl Antibody
- MDA5 Antibody
- NXP2 Antibody
- TIF1 Antibody
- SSA-52 kd IgG Antibody
- U1 RNP Antibody
- Fibrillarin U3 RNP Antibody
- Myositis Specific Antibodies (MSA)
Specimen Requirements
Collect specimen in TWO (2) Red top or SST tubes. Centrifuge within an hour, and aliquot serum into a screw capped, plastic vial. Send to Specimen Processing refrigerated.
Test requires a large volume of serum. It will be canceled if a minimum of 4 mLs of serum are not received. Please collect TWO (2) 6.0 mL red tops or SST's for this test alone.
Additional Information
Panel includes Jo-1, Mi-2, PL-12, PL-7, EJ, OJ, SRP, Ku, U2 RNP, PM-Scl, MDA5, NXP2, TIF1, SSA 52 kD IgG, U1 RNP, and Fibrillarin U3 RNP. Test sent to Mayo Clinic Laboratories; performed by Esoterix Endocrinology