Test Overview
Test Methodology

Chemiluminescent Immunoassay

Test Usage

The most common indication for ordering the MBP test is in the differential diagnosis of Multiple Sclerosis (MS). Elevated concentrations of MBP in the CSF is only an indication of demyelination, which can occur in clinical contexts other than MS. Therefore, elevated concentration of MBP in the CSF should not be considered as a diagnostic marker for MS. Recent revisions to the diagnostic criteria for MS include CSF oligoclonal IgG bands and/or increased IgG index, but not MBP measurements.

Reference Range *

0.0 - 5.50 ng/mL

Test Details
Days Set Up
Sunday-Saturday
Analytic Time

2 - 5 days

Soft Order Code
SO
Synonyms
  • CSF, Myelin Basic Protein
  • MBP
  • Multiple Sclerosis (MS)
  • Spinal Fluid, Myelin Basic Protein
  • MBPC
  • MYELIN BASIC PROTEIN, CSF
Laboratory
Sendout
Reference Laboratory
ARUP 0080515
Section
Special Testing
Specimen Requirements
Collection Instructions

Place CSF in a clean plastic screw capped tube or container and freeze.

Normal Volume
1 mL CSF
Minimum Volume
0.3 mL CSF
Additional Information

Hemolysis is associated with falsely-elevated levels of MBP in the cerebrospinal fluid. CSF should be free from contamination with blood, if possible. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing the sample. Test sent to ARUP Laboratories.

Billing
CPT Code
83873
Fee Code
21977
LOINC
2638-5
NY State Approved
No