Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the MYC gene region (8q24) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual color break apart probe (Abbott Molecular) to qualitatively assess for the presence of MYC translocations that occur in B-cell lymphomas. Testing for MYC gene rearrangement may aid in the diagnosis of Burkitt lymphoma, and may indicate an aggressive clinical course in other B-cell lymphomas.
Interpretive report provided.
This test will detect rearrangements involving MYC, however it will not identify the translocation partner. In addition, this test may fail to detect a translocation in a sample with a low neoplastic burden.
3 - 10 days
- LSI MYC t(8q;24) by FISH
- FISH for Burkitt Lymphoma
- c-MYC (8q24) FISH
- MYC (8q24) Rearrangement FISH
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.