Update Type: Test Resumed
Test Updated: 09/20/2023
Test Overview
Test Usage

Recommended for patients presenting with an acquired defect of neuromuscular transmission in whom the differential diagnosis includes LES. It is not recommended for patients with a past history of, or risk factors for, lung cancer and/or concurrent neurological symptoms/signs not attributable to LES; for those situations, order Paraneoplastic Autoantibody Evaluation (Mayo 83380). Testing for a newly recognized alternative antibody of MG (muscle-specific receptor tyrosine kinase [MuSK]) is indicated when all tests are negative. MuSK antibody testing is available on request.

Reference Range *

Muscle AChR Binding Ab: <=0.02 nmol/L; Muscle AChR Modulating Ab: 0 - 20%; Striational Ab: <1:120; P/Q Type Calcium Channel Binding Ab: <0.02 nmol/L; N Type Calcium Channel Binding Ab: <0.03 nmol/L; CRMP-5-IgG Western Blot: Negative; AChR Ganglionic Neuronal Ab: <=0.02 nmol/L.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Analytic Time

3 - 11 days

Soft Order Code
  • Acetylcholine Receptor Antibodies
  • ACh Receptor (Muscle) Binding Antibody
  • ACh Receptor (Muscle) Modulating Antibody
  • AChR Ganglionic Neuronal Antibody (reflex)
  • CRMP-5 IgG (reflex)
  • Striational (Striated Muscle) Antibody
  • AChR Antibodies
  • P/Q Type Calcium Channel Antibody
  • N Type Calcium Channel Antibody
  • CRMP-5-IgG Western Blot, S
  • AChR Ganglionic Neuronal Ab, S
  • C5BLOT
  • MG1
Reference Laboratory
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Normal Volume
3 mL serum
Minimum Volume
2 mL serum
Storage Temperature
Refrigerated preferred, frozen acceptable
Additional Information

Evaluation includes the following tests: Calcium Channel Binding Ab P/Q Type, Calcium Channel Binding Ab N Type, AChR Binding Ab, AChR Modulating Ab, and Striational Ab. The following tests are reflexed at an additional charge when indicated: AChR Ganglionic Neuronal Ab (ACHRG) and CRMP-5-IgG Western Blot (C5BLOT). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.

CPT Code
83519, 86596
Fee Code
32034, AB001
Reflex CPT
ACMFS 86255, MUSK 83519
Reflex Fee Code
ACMFS AA930, MUSK 21611