Test Overview

Test Usage

Recommended for patients presenting with an acquired defect of neuromuscular transmission in whom the differential diagnosis includes LES. It is not recommended for patients with a past history of, or risk factors for, lung cancer and/or concurrent neurological symptoms/signs not attributable to LES; for those situations, order Paraneoplastic Autoantibody Evaluation (Mayo 83380). Testing for a newly recognized alternative antibody of MG (muscle-specific receptor tyrosine kinase [MuSK]) is indicated when all tests are negative. MuSK antibody testing is available on request.

Reference Range*

Muscle AChR Binding Ab: <=0.02 nmol/L; Muscle AChR Modulating Ab: 0 - 20%; Striational Ab: <1:120; P/Q Type Calcium Channel Binding Ab: <0.02 nmol/L; N Type Calcium Channel Binding Ab: <0.03 nmol/L; CRMP-5-IgG Western Blot: Negative; AChR Ganglionic Neuronal Ab: <=0.02 nmol/L.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Analytic Time

3 - 7 days

Soft Order Code


Test Updated

Update Type: Test Down or Delayed

Updated Date: 09/04/2019



Acetylcholine Receptor Antibodies
ACh Receptor (Muscle) Binding Antibody
ACh Receptor (Muscle) Modulating Antibody
AChR Ganglionic Neuronal Antibody (reflex)
CRMP-5 IgG (reflex)
Striational (Striated Muscle) Antibody
AChR Antibodies
P/Q Type Calcium Channel Antibody
N Type Calcium Channel Antibody
CRMP-5-IgG Western Blot, S
AChR Ganglionic Neuronal Ab, S

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Laboratory Reference

Mayo MGL1

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.


Yellow Top Tube

Normal Volume

3 mL serum

Minimum Volume

2 mL serum

Additional Information

Evaluation includes the following tests: Calcium Channel Binding Ab P/Q Type, Calcium Channel Binding Ab N Type, AChR Binding Ab, AChR Modulating Ab, and Striational Ab. The following tests are reflexed at an additional charge when indicated: AChR Ganglionic Neuronal Ab (ACHRG) and CRMP-5-IgG Western Blot (C5BLOT). By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test sent to Mayo Medical Laboratories.

Billing Information

Fee Codes

CPT Code

83519 x4, 83520

Reflex Fee Code

ACHRG 36139, C5BLOT 36140

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