Update Type: Reference range changed
Test Updated: 09/21/2022
Test Overview
Test Methodology

KCSFP: Nephelometry
OLIGC, OLIGS: Isoelectric Focusing (IEF) with IgG Immunoblot Detection

Test Usage

Diagnosing multiple sclerosis, especially helpful in patients with equivocal clinical or radiological findings

Reference Range *

Kapp Free Light Chains: Medical decision point: 0.1000 mg/dL
Oligoclonal bands: <2 bands

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

4 - 6 days

Soft Order Code
Reference Laboratory
Mayo MSP3
Special Testing
Specimen Requirements

Collect serum in an SST or red top tube. Spin and aliquot within 2 hours of collection, into a screw capped plastic tube. Label the aliquot as serum. Send to Specimen Processing frozen.
Collect CSF in a screw capped plastic tube. Label as CSF, and send to Specimen Processing frozen.

Special Handling

Serum and CSF must be collected within 7 days of each other

Normal Volume
Serum: 1 mL; CSF: 1 mL
Minimum Volume
Serum: 0.5 mL; CSF: 0.5 mL
Storage Temperature
Additional Information

Kappa free light chain will be performed by nephelometry on all samples. When kappa free light chain results are 0.0600 mg/dL or more, the oligoclonal banding tests will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. Test performed by Mayo Clinic Laboratories

CPT Code
Fee Code