To differentiate between monoclonal and polyclonal gammopathies. To identify and type monoclonal immunoglobulins for heavy and light chain specificity. Monoclonal gammopathy evaluation (MGE) is essential when clinical, hematologic, or pathologic findings indicate: multiple myeloma, Waldenstrom's, heavy chain disease, amyloidosis, or Ig deposition disease. MGE is also essential in the presence of abnormal bands on serum protein electrophoresis (TPE), in cryoglobulins, in Bence Jones proteinuria, in pyroglobulins, and in hyperviscosity syndrome. If light chain disease is part of the differential diagnosis, submit a urine specimen for Bence Jones Protein Screen.