A positive test for Mitochondrial antibody in the presence of increased alkaline phospatase activity, elevated cholesterol, and elevated IgM concentrations, strongly supports the diagnosis of primary biliary cirrhosis (PBC). The liver mitochondrial antibody is generally absent in drug-induced cholestatic jaundice, viral hepatitis, sclerosing cholangitis, alcoholic and other forms of cirrhosis, hepatic malignancy, and other autoimmune diseases. Low titer antibody may be found in other autoallergic hepatic disorders, such as chronic active hepatitis and cryptogenic cirrhosis. If another antibody including Parietal Cell Antibody, Liver Kidney Microsomal Antibody, or Smooth Muscle Antibody, is noted to be present during the performance of this test, the client will be notified via a footnote in the report. Please contact the MLabs Client Services Center to request the additional auto-antibody; there will be a separate charge for each auto-antibody test ordered.