Useful in providing confirmatory evidence in the diagnosis of primary biliary cirrhosis.
Reference Range*
Negative
* Reference ranges may change over time.
Please refer to the original patient report when evaluating results.
Test Limitations
Level of antibody does not correlate with severity or duration of disease. Low, transient titers are sometimes seen with chlorpromazine or halothane sensitivity.
Test Details
Days Test Performed
Tuesday, Friday
Analytic Time
8 hours
Soft Order Code
MITO
MiChart Code
Antimitochondrial Antibody
Synonyms
Synonyms
AMA
Antimitochondrial Antibody
Liver Mitochondrial Antibody
Mito
Mito Ab
Mitochondrial Antibody
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Specimen Requirements
Offsite Collection Instructions
Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.
Container
Normal Volume
0.5 mL serum
Minimum Volume
0.2 mL serum
Additional Information
A positive test for Mitochondrial antibody in the presence of increased alkaline phospatase activity, elevated cholesterol, and elevated IgM concentrations, strongly supports the diagnosis of primary biliary cirrhosis (PBC). The liver mitochondrial antibody is generally absent in drug-induced cholestatic jaundice, viral hepatitis, sclerosing cholangitis, alcoholic and other forms of cirrhosis, hepatic malignancy, and other autoimmune diseases. Low titer antibody may be found in other autoallergic hepatic disorders, such as chronic active hepatitis and cryptogenic cirrhosis. If another antibody including Parietal Cell Antibody, Liver Kidney Microsomal Antibody, or Smooth Muscle Antibody, is noted to be present during the performance of this test, the client will be notified via a footnote in the report. Please contact the MLabs Client Services Center to request the additional auto-antibody; there will be a separate charge for each auto-antibody test ordered.
