Test Overview

Test Methodology

Indirect Fluorescent Antibody (IFA), Mouse stomach kidney substrate

Test Usage

Useful in providing confirmatory evidence in the diagnosis of primary biliary cirrhosis.

Reference Range*


* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Level of antibody does not correlate with severity or duration of disease. Low, transient titers are sometimes seen with chlorpromazine or halothane sensitivity.

Test Details

Days Test Performed

Tuesday, Friday

Analytic Time

8 hours

Soft Order Code


MiChart Code

Antimitochondrial Antibody



Antimitochondrial Antibody
Liver Mitochondrial Antibody
Mito Ab
Mitochondrial Antibody

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Chemical Pathology

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.


Yellow Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.2 mL serum

Additional Information

A positive test for Mitochondrial antibody in the presence of increased alkaline phospatase activity, elevated cholesterol, and elevated IgM concentrations, strongly supports the diagnosis of primary biliary cirrhosis (PBC). The liver mitochondrial antibody is generally absent in drug-induced cholestatic jaundice, viral hepatitis, sclerosing cholangitis, alcoholic and other forms of cirrhosis, hepatic malignancy, and other autoimmune diseases. Low titer antibody may be found in other autoallergic hepatic disorders, such as chronic active hepatitis and cryptogenic cirrhosis. If another antibody including Parietal Cell Antibody, Liver Kidney Microsomal Antibody, or Smooth Muscle Antibody, is noted to be present during the performance of this test, the client will be notified via a footnote in the report. Please contact the MLabs Client Services Center to request the additional auto-antibody; there will be a separate charge for each auto-antibody test ordered.

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