Mitochondrial Ab: A positive test for Mitochondrial antibody in the presence of increase alkaline phosphatase activity, elevated cholesterol, and elevated IgM concentrations, strongly supports the diagnosis of primary biliary cirrhosis (PBC). The liver mitochondrial antibody is generally absent in drug-induced cholestatic jaundice, viral hepatitis, sclerosing cholangitis, alcoholic and other forms of cirrhosis, hepatic malignancy, and other immune diseases.
Smooth Muscle Ab: Smooth muscle antibody measurements are useful in confirming the diagnosis of chronic active hepatitis (CAH). Titers generally range from 1:80 - 1:320 and persist for years. In viral hepatitis the titers are below 1:80 and are transient. Low titers (1:20 to 1:40) are found in approximately 50% of patients with primary biliary cirrhosis. If another antibody including Parietal Cell Antibody, Mitochondrial Antibody, or Liver Kidney Microsomal Antibody is noted to be present during the performance of this test, the client will be notified via comment in the report. Please contact MLabs Client Services Center to request the additional auto-antibody; there will be a separate charge for each auto-antibody test ordered.