Test Overview
Test Methodology

Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)

Test Usage

Monitor therapy for patients with methylmalonic aciduria. The rate of urinary methylmalonic acid excretion is usually elevated in patients with occult cobalamin deficiency. Methylmalonate accumulates in man when a cobalamin deficiency state exists which is identified by low normal levels of vitamin B12. Quantitation of urine methylmalonate provides for a functional test for adequacy of this vitamin.

Reference Range *

< 3.60 mmol/mol creatinine

Test Details
Days Set Up
Monday, Thursday
Analytic Time

4 - 6 days

Soft Order Code
MMAU
MiChart Code
Methylmalonic Acid, Urine
Synonyms
  • Methylmalonate
  • Methylmalonate, Urine
  • MMA
  • MMA, Urine
  • MMAU
  • METHYLMALONIC ACID URINE
Laboratory
Sendout
Reference Laboratory
Mayo MMAU (80290)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect random urine; second voided specimen after an overnight fast. Transfer aliquot to plastic container and freeze. Indicate "urine" on request form.

Special Handling

Fasting specimen.

Normal Volume
4.0 ml
Minimum Volume
1.2 ml
Additional Information

Test sent for Mayo Medical Laboratories.

Billing
CPT Code
83921
Fee Code
22000
LOINC
2630-2
NY State Approved
No