Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)
Monitor therapy for patients with methylmalonic aciduria. The rate of urinary methylmalonic acid excretion is usually elevated in patients with occult cobalamin deficiency. Methylmalonate accumulates in man when a cobalamin deficiency state exists which is identified by low normal levels of vitamin B12. Quantitation of urine methylmalonate provides for a functional test for adequacy of this vitamin.
< 3.60 mmol/mol creatinine
4 - 6 days
- Methylmalonate, Urine
- MMA, Urine
- METHYLMALONIC ACID URINE
Collect random urine; second voided specimen after an overnight fast. Transfer aliquot to plastic container and freeze. Indicate "urine" on request form.
Test sent for Mayo Medical Laboratories.