Fractionated Metanephrines, Urine
Fractionation, Metanephrines and Normetanephrines
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Evaluate presence of abnormal catecholamine production, may be elevated when VMA and catecholamines are within normal limits. Useful in the diagnosis of pheochromocytoma, neuroblastoma, ganglioneuroblastoma, and hypertension.
Metanephrines: 0-300 mcg/24 hrs, Normetanephrines: 50-800 mcg/24 hrs
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 20 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 20 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Patient must be off Aldomet (alpha methyldopa) and its derivatives for a period of not less than 5 weeks. This drug will falsely elevate the metanephrines and normetanephrines. A 12 hr overnight collection will be accepted, but reference ranges have been established only for 24 hr collections.