Test Overview

Test Methodology

Tandem Mass Spectrometry (UPLC-MS/MS)

Test Usage

Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas.

Reference Range*

Metanephrine, Plasma <0.5 nmol/L; Normetanephrine, Plasma <0.9 nmol/L.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

While most circulating metanephrines are derived directly from adrenal secretion, peripheral conversion of catecholamines makes a small contribution. Therefore, substances that increase endogenous catecholamine levels can result in borderline elevations of plasma metanephrines. These include monamine oxidase inhibitors (MOIs), catecholamine reuptake inhibitors, and some anesthetic gases, particularly halothane. Artifactually decreased plasma metanephrine levels may be observed when patients are already receiving metyrosine treatment.

Test Details

Days Test Performed

Varies; test performed twice per week

Analytic Time

8 hours

Soft Order Code


MiChart Code

Metanephrines, Plasma Fractions



Normetanephrines, Plasma
Fractionated Metanephrines, Plasma
Metanephrines, Fract., Free, P

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Chemical Pathology

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Specimen Requirements

Special Handing

Fasting specimen.


Lavender Top Tube

Normal Volume

1 mL EDTA plasma

Minimum Volume

0.5 mL EDTA plasma

Billing Information

Fee Codes

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