Tandem Mass Spectrometry (UPLC-MS/MS)
Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas.
Metanephrine, Plasma <0.5 nmol/L; Normetanephrine, Plasma <0.9 nmol/L.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
While most circulating metanephrines are derived directly from adrenal secretion, peripheral conversion of catecholamines makes a small contribution. Therefore, substances that increase endogenous catecholamine levels can result in borderline elevations of plasma metanephrines. These include monamine oxidase inhibitors (MOIs), catecholamine reuptake inhibitors, and some anesthetic gases, particularly halothane. Artifactually decreased plasma metanephrine levels may be observed when patients are already receiving metyrosine treatment.
Days Test Performed
Varies; test performed twice per week
Soft Order Code
Metanephrines, Plasma Fractions
Fractionated Metanephrines, Plasma
Metanephrines, Fract., Free, P
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1 mL EDTA plasma
0.5 mL EDTA plasma