3 - 10 days
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Fluorescence In Situ Hybridization (FISH)
This test detects amplification of the MET gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using Vysis probes (Abbott Molecular, Inc) targeting the MET locus (7q31) and the chromosome 7 centromere (CEP7). Results are reported as a MET:CEP7 copy number ratio and average MET copy number (signals/cell). MET amplification status can be a useful adjunct indicator of prognosis, and can assist in the selection of patients for whom tyrosine kinase inhibitors treatment is being considered.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.