Test Overview
Test Methodology

Fluorescence In Situ Hybridization (FISH)

Test Usage

This test detects aneuploidy for chromosomes 3, 7, 17, and loss of the 9p21 locus via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded specimens including resections, biopsies and cytology cell blocks. Positive results are consistent with a diagnosis of malignant mesothelioma; however, a positive result by this test is not specific for mesothelioma. Metastatic carcinoma may also demonstrate a positive result.

Reference Range *

Interpretive report provided.

Test Limitations

A negative result may be obtained in patients with malignant mesothelioma if insufficient malignant cells are present within the sample. This result also does not rule out the presence of malignant mesothelioma that lacks the chromosomal abnormalities evaluated by this test.

Test Details
Days Set Up
Monday - Thursday
Analytic Time

3 - 10 days

Soft Order Code
MMESO
MiChart Code
Mesothelioma FISH
Laboratory
Molecular Diagnostics
Section
Molecular Diagnostics
Specimen Requirements
Collection Instructions

A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.

Normal Volume
Formalin-fixed, paraffin-embedded tissue
Additional Information

By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.

Billing
CPT Code
88377-TC
Fee Code
NA095
Pro Fee CPT
88377-26
NY State Approved
No