High Performance Liquid Chromatography (HPLC)
Therapeutic drug monitoring of Mercaptopurine (6-MP) (Purinethol) or Azathioprine (Imuran) (measured as 6-Mercaptopurine).
Therapeutic and toxic ranges have not been established. Usual therapeutic doses of either mercaptopurine or azathioprine produce 6-mercaptopurine serum concentrations of less than 1000 ng/mL.
5 - 11 days
- 6 Mercaptopurine (6 MP)
- Mercaptopurine (6-MP) Level
Collect specimen in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into a plastic vial and refrigerate.
Mercaptopurine may be administered as an antineoplastic or may be present as a metabolite of the immunosuppressant drug azathioprine. Test sent to Mayo Medical Laboratories; performed by MedTox Laboratories.