Update Type: Miscellaneous
Test Updated: 07/05/2023
Test Overview
Test Methodology


Test Usage

To help in the diagnosis of biliary atresia

Reference Range *

3.6 - 10.5 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

MMP-7 level ≥ 18.2 ng/mL has 95% sensitivity and 65% specificity for diagnosis of biliary atresia, with negative predictive value of 97%.

Caution should be exercised in the interpretation of any assay for MMP-7, and the results should be considered in conjunction with the patient’s clinical condition. High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct. The normal values of MMP-7 in premature babies have not yet been established. Clinical correlation is particularly important in premature babies.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

3 - 4 days

Soft Order Code
MiChart Code
Reference Laboratory
Children's Medical Center of Dallas
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in SST or red top tube. Place specimen on ice immediately after collection. Spin, aliquot and freeze within 2 hours of collection. Ship to Dallas Monday-Thursday only. Store frozen over the weekend if one is received on a Friday in sendouts

Special Handling

Place on ice immediately after collection. Spin, aliquot and freeze within 2 hours of collection
Ship Monday - Thursday only. Lab is not open on weekends. Store frozen if one is received on a Friday in Sendouts

Normal Volume
1.5 mL serum
Minimum Volume
0.5 mL serum
Storage Temperature
Strict frozen
Additional Information

Test is performed by Children's Medical Center of Dallas

CPT Code
Fee Code