Fluorescence In Situ Hybridization (FISH)
This test detects rearrangements involving the MALT1 gene region (18q21) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color break-apart probe (Abbott Molecular) to qualitatively assess for the presence of MALT1 translocations that occur in approximately 25% of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) cases. Testing for MALT1 gene rearrangement may aid in the diagnosis and classification of these tumors.
Interpretive report provided.
This test will detect rearrangements involving MALT1, but it will not identify the translocation partner. In addition, this test may fail to detect a translocation in a sample with a low neoplastic burden.
3 - 10 days
- MALT1 (18q21) FISH
- Mucosa-associated Lymphoid Tissue (MALT)
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.
By ordering this test the clinician acknowledges that informed consent has been obtained from the patient as required by applicable state or federal laws and the ordering clinician has authorization from the patient permitting MLabs to report the test results to the ordering clinician. Test includes pathologist interpretation of results billed as a separate additional charge. This test is not available without interpretation.