Flow Cytometric Immunophenotyping
As an aid in the diagnosis of LAD-1 syndrome, primarily in patients <18 years of age.
Normal (reported as normal or absent expression for each marker)
Patients with normal beta2-integrin expression without functional activity have been described.(5-6) Therefore, expression of CD18 alone is insufficient to exclude the diagnosis of LAD-1; functional assays (eg, neutrophil chemotaxis, random migration assays) must be performed if the clinical suspicion is high.
3 - 4 days
- Leukocyte Adhesion Deficiency (LAD)
- MO1 Deficiency
- Neutrophil Adherence
- Neutrophil Function Assay
- NEUT ADHER
- Neut. Adher. Shadow
- CD11a Phenotyping
- CD11b Phenotyping
- CD18 Phenotyping
- CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping
Collect specimen in a lavender top tube. Send intact whole blood at room temperature. Do not refrigerate or freeze. Specimens must be received by the performing laboratory Monday - Friday and within 24 hours of collection. It is recommended that for serial monitoring specimen draws be performed at the same time of day.
Specimens must be received by the performing laboratory Monday - Friday and within 24 hours of collection.
Test sent to Mayo Medical Laboratories.