Test Overview
Test Methodology

Flow Cytometric Immunophenotyping

Test Usage

As an aid in the diagnosis of LAD-1 syndrome, primarily in patients <18 years of age.

Reference Range *

Normal (reported as normal or absent expression for each marker)

Test Limitations

Patients with normal beta2-integrin expression without functional activity have been described.(5-6) Therefore, expression of CD18 alone is insufficient to exclude the diagnosis of LAD-1; functional assays (eg, neutrophil chemotaxis, random migration assays) must be performed if the clinical suspicion is high.

Test Details
Days Set Up
Monday - Friday
Analytic Time

3 - 4 days

Soft Order Code
MMLR
Synonyms
  • Leukocyte Adhesion Deficiency (LAD)
  • MO1 Deficiency
  • Neutrophil Adherence
  • Neutrophil Function Assay
  • NEUT ADHER
  • NADS
  • Neut. Adher. Shadow
  • CD11a Phenotyping
  • CD11b Phenotyping
  • CD18 Phenotyping
  • CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping
Laboratory
Sendout
Reference Laboratory
Mayo LAD1
Section
Special Testing
Specimen Requirements
Collection

Collect specimen in a lavender top tube. Send intact whole blood at room temperature. Do not refrigerate or freeze. Specimens must be received by the performing laboratory Monday - Friday and within 24 hours of collection. It is recommended that for serial monitoring specimen draws be performed at the same time of day.

Special Handling

Specimens must be received by the performing laboratory Monday - Friday and within 24 hours of collection.

Contraindications
This test is typically not indicated in adults.
Lavender Top Tube
Normal Volume
5 mL whole blood
Minimum Volume
2 mL whole blood
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
88184, 88185 x2
NY State Approved
No