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Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Verifying systemic absorption of orally administered itraconazole. This test is indicated in patients with life-threatening fungal infections and in patients considered at risk for poor absorption or rapid clearance.
Itraconazole (trough): >0.5 mcg/mL (localized infection); >1.0 mcg/mL (systemic infection). Hydroxyitraconazole: No therapeutic range established; activity and serum concentration are similar to parent drug.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Collect specimen in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. For maximum clinical significance, usual sampling times are Peak: 30 minutes after the end of an I.V. infusion (60 minutes after I.M. or oral administration) or Trough: immediately before next dose is given.