Test Overview
Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Verifying systemic absorption of orally administered itraconazole. This test is indicated in patients with life-threatening fungal infections and in patients considered at risk for poor absorption or rapid clearance.

Reference Range *

Itraconazole (trough): >0.5 mcg/mL (localized infection); >1.0 mcg/mL (systemic infection). Hydroxyitraconazole: No therapeutic range established; activity and serum concentration are similar to parent drug.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday through Saturday
Analytic Time

1 - 3 days

Soft Order Code
ITCON
MiChart Code
Itraconazole Level
Synonyms
  • Sporanox
Laboratory
Sendout
Reference Laboratory
Mayo ITCON (81247)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate. For maximum clinical significance, usual sampling times are Peak: 30 minutes after the end of an I.V. infusion (60 minutes after I.M. or oral administration) or Trough: immediately before next dose is given.

Normal Volume
1 mL serum
Minimum Volume
0.2 mL serum
Rejection Criteria
SST tube not acceptable.
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
80189
Fee Code
22035
NY State Approved
No