Interleukin 28B Variant (rs12979860)

Test Overview

Test Methodology

Real-Time Polymerase Chain Reaction (PCR) with Allelic Discrimination Analysis

Test Usage

Predicting responsiveness of genotype 1 hepatitis C viral infections to combined pegylated-interferon and ribavirin-based therapies. Samples may contain donor DNA if obtained from patients who received heterologous blood transfusions or allogeneic blood or marrow transplantation. Results from samples obtained under these circumstances may not accurately reflect the recipient's genotype. For individuals who have received blood transfusions, the genotype usually reverts to that of the recipient within 6 weeks. For individuals who have received allogeneic blood or marrow transplantation, a pretransplant DNA specimen is recommended for testing. For liver transplant patients, the IL28B genotype of the recipient and the donor are independent predictors of sustained virologic response with combined pegylated-interferon and ribavirin therapy.

Reference Range *

Interpretive report provided.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

This test does not detect polymorphism or mutations other than the single-nucleotide polymorphism (SNP) of rs12979860 C/T. Rare polymorphisms exist and could lead to false-negative or false-positive results.

Test Details

Days Set Up

Monday - Friday

Analytic Time

3 - 8 days

Soft Order Code

BIL28

MiChart Code

Interleukin 28B Polymorphism Genotype

Synonyms

IL28B
IL28B Polymorphism Genotype
IL28B Polymorphism (rs12979860)

Laboratory

Sendout

Reference Laboratory

Mayo IL28V

Section

Special Testing

Specimen Requirements

Collection Instructions

Collect specimen in a lavender top tube. Send intact blood at room temperature. Note that this test should be performed only once per patient lifetime on patients who are proven to be HCV positive.