Test Overview
Real-Time Polymerase Chain Reaction (PCR) with Allelic Discrimination Analysis
Predicting responsiveness of genotype 1 hepatitis C viral infections to combined pegylated-interferon and ribavirin-based therapies. Samples may contain donor DNA if obtained from patients who received heterologous blood transfusions or allogeneic blood or marrow transplantation. Results from samples obtained under these circumstances may not accurately reflect the recipient's genotype. For individuals who have received blood transfusions, the genotype usually reverts to that of the recipient within 6 weeks. For individuals who have received allogeneic blood or marrow transplantation, a pretransplant DNA specimen is recommended for testing. For liver transplant patients, the IL28B genotype of the recipient and the donor are independent predictors of sustained virologic response with combined pegylated-interferon and ribavirin therapy.
Interpretive report provided.
This test does not detect polymorphism or mutations other than the single-nucleotide polymorphism (SNP) of rs12979860 C/T. Rare polymorphisms exist and could lead to false-negative or false-positive results.
Test Details
3 - 8 days
- IL28B
- IL28B Polymorphism Genotype
- IL28B Polymorphism (rs12979860)
Specimen Requirements
Collect specimen in a lavender top tube. Send intact blood at room temperature. Note that this test should be performed only once per patient lifetime on patients who are proven to be HCV positive. Saliva kit and extracted DNA are also acceptable
Additional Information
Test sent to Mayo Medical Laboratories.