Update Type: Test Down or Delayed
Test Updated: 07/28/2021
Test Overview
Test Methodology

Enzyme Immunoassay (EIA)

Test Usage

Interleukin 1b is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells. The major target cells are T and B cells, Fibroblasts, and Hepatocytes and it has pyrogenic activity. Interleukin 1b shares a receptor with Interleukin 1a although they are significantly different structurally. Interleukin 1b promotes antigen specific immune responses, inflammation, secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, acute phase response, and cartilage resorption. Interleukin 1b increases accumulation of cell-associated and extracellular arachadonic acid, and induces release of Interleukin 6.

Reference Range *

< 1.0 pg/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday
Analytic Time

10 - 15 days

Soft Order Code
  • Cytokine IL1b
  • Interleukin-1b
  • IL-1b
  • Interleukin 1-Beta
Reference Laboratory
Mayo FINTB (91719) (Interscience)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and freeze. Patient should not be on any Corticosteroids, anti-inflammatory medications or pain killers, if possible, for at least 48 hours prior to specimen collection.

Special Handling

Specimen must be spun, aliquoted and frozen immediately.

Normal Volume
3 mL serum
Minimum Volume
1 mL serum
Additional Information

Test sent to Mayo Medical Laboratories; performed by InterScience Institute.

CPT Code