Test Overview
Test Methodology

IGFBP-3: Enzyme-Labeled Chemiluminescent Immunometric Assay, IGF-1: Liquid Chromatography-Mass Spectrometry (LC-MS).

Test Usage

In combination with IGF-1 measurements, IGFBP-3 measurements are useful for the diagnosis of growth disorders, the diagnosis of adult GH-deficiency, monitoring of rhGH treatment, and as a possible adjunct to IGF-1 and GH in the diagnosis and follow-up of acromegaly and gigantism. At this time, IGFBP-3 cannot be reliably used as a prognostic marker in breast, colon, prostate or lung cancer.

Reference Range *

Age specific ranges provided with report.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

IGF-1 assays exhibit significant variability among platforms and manufacturers. Direct comparison of results obtained by different assays is problematic. Re-baselining of patients is recommended if assays are changed.

Test Details
Days Set Up
Monday - Friday
Analytic Time

5 - 9 days

Soft Order Code
MiChart Code
Growth Factor Panel
  • Insulin-Like Growth Factor Growth Assessment Group
  • Growth Assessment Group V
  • IGF-1 and IGFBP-3
  • Growth Assessment Group V
  • Growth Factor Panel
  • IGFBP-3
  • IGF-1
  • IGFBP3
  • IGF-I Blocking
  • IGF Binding Protein (IGFBP-3)
  • IGF-1 and IGFBP-3 Growth Panel
  • IGF Binding Protein-3, Serum
Reference Laboratory
Mayo IGFGP (36365)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into two equal portions, and freeze.

Normal Volume
1 mL serum
Minimum Volume
0.5 mL serum
Storage Temperature
Strict frozen
Additional Information

Test includes Insulin-Like Growth Factor Binding Protein (IGFBP-3) and Insulin-Like Growth Factor (IGF-1). Test sent to Mayo Medical Laboratories.

CPT Code
84305 IGF-1, 83520 IGFBP3
Fee Code
22008 IGF-1, 22009 IGFBP3