Test Overview

Test Methodology

Enzyme-Labeled Chemiluminescent Immunometric Assay

Test Usage

In combination with IGF-1 measurements, IGFBP-3 measurements are useful for the diagnosis of growth disorders, the diagnosis of adult GH-deficiency, monitoring of rhGH treatment, and as a possible adjunct to IGF-1 and GH in the diagnosis and follow-up of acromegaly and gigantism. At this time, IGFBP-3 cannot be reliably used as a prognostic marker in breast, colon, prostate or lung cancer.

Reference Range*

Age specific ranges provided with report.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

IGFBP-3 assays exhibit significant variability among platforms and manufacturers. Direct comparison of results obtained by different assays is problematic. Re-baselining of patients is recommended if assays are changed.

Test Details

Days Test Performed

Monday - Saturday

Analytic Time

1 - 3 days

Soft Order Code


MiChart Code

Insulin-Like Growth Factor Binding Protein

Test Updated

Update Type: Specimen collection or handling and/or storage changed

Updated Date: 07/29/2020



IGF Binding Protein
IGF Binding Protein-3, Serum

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Laboratory Reference

Mayo IGFB3 (83300)

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.


Yellow Top Tube

Normal Volume

0.8 mL serum

Minimum Volume

0.3 mL serum

Additional Information

Test sent to Mayo Medical Laboratories.

Billing Information

Fee Codes

CPT Code


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