Test Overview
Test Methodology

Enzyme-Labeled Chemiluminescent Immunometric Assay

Test Usage

In combination with IGF-1 measurements, IGFBP-3 measurements are useful for the diagnosis of growth disorders, the diagnosis of adult GH-deficiency, monitoring of rhGH treatment, and as a possible adjunct to IGF-1 and GH in the diagnosis and follow-up of acromegaly and gigantism. At this time, IGFBP-3 cannot be reliably used as a prognostic marker in breast, colon, prostate or lung cancer.

Reference Range *

Age specific ranges provided with report.

Test Limitations

IGFBP-3 assays exhibit significant variability among platforms and manufacturers. Direct comparison of results obtained by different assays is problematic. Re-baselining of patients is recommended if assays are changed.

Test Details
Days Set Up
Monday - Saturday
Analytic Time

1 - 3 days

Soft Order Code
MiChart Code
Insulin-Like Growth Factor Binding Protein
  • IGF Binding Protein
  • IGFBP-3
  • IGFBP3
  • IGF Binding Protein-3, Serum
Reference Laboratory
Mayo IGFB3 (83300)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top or SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.

Yellow Top Tube
Normal Volume
0.8 mL serum
Minimum Volume
0.3 mL serum
Additional Information

Test sent to Mayo Medical Laboratories.

CPT Code
Fee Code
NY State Approved