8 - 48 hrs
Test Updated:
B and T Cell Typing for Lymphocytic Leukemias
Leukemia / Lymphoma Immunophenotyping
Lymphocyte Typing for Lymphoproliferative Disorders
Lymphocytic Leukemias, Acute and Chronic Subtyping
T and B Cell Typing for Lymphocytic Leukemias
Leukemias, Acute
Leukemias, Chronic
Chronic Lymphocytic Leukemia (CLL)
Mixed Linage Acute Leukemia
Acute Lymphocytic Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Leukemia/Lymphoma, Uncertain Subtype
Plasma Cell Panel (PCL)
ACUTE
NONACUTE
LEUKS
ACUTE MARKER PANEL
NONACUTE MARKER PANEL
COMBO
Leukemia/Lymphoma Workup
Prolymphocytic Leukemia (PLL)
Mantle Cell Lymphoma/Leukemia (MCL)
Hairy Cell Leukemia (HCL)
Non-Hodgkin's Lymphoma
Follicular Lymphoma
Diffuse Large B-Cell Lymphoma (DLBCL)
Leukemia/Lymphoma Acute Marker Panel
Leukemia/Lymphoma Nonacute Marker Panel
Leukemia/Lymphoma Combo Marker Panel
Panel 3: Plasma Cell / Multiple Myeloma
Panel 1: Stem Cell Neoplasm / Acute Leukemia
Panel 2: Mature Lymphoid Leukemia / Non-Hodgkin Lymphoma
Panel 4: Comprehensive Leukemia / Lymphoma
Multiple Myeloma
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Test Overview
Direct immunofluorescence using flow cytometric techniques.
Confirmation of diagnosis and immunophenotype in acute and chronic leukemias and lymphomas. See http://www.pathology.med.umich.edu/handbook/Tables/Flow_Cytometry_Panel… for all Flow Cytometry Panels.
Pathologist interpretation of results provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Specimen Requirements
The following information is required on a Hematopathology Consult requisition:
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Relevant clinical history
Clinical or morphological findings and suspicions
Specimen source
Date and time of collection
Phone number and after hours pager number for ordering physician
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[bold]BONE MARROW ASPIRATE:[/bold]
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Add 1 - 2 ml of first pull bone marrow aspirate to a green top sodium heparin Vacutainer® tube. Send intact specimen at room temperature within 12 hours of collection.
Include 4 unstained aspirate smears
Include an unstained peripheral blood smear
Include a copy of the patient's most recent White Blood Cell and platelet counts, and peripheral blood differential.
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[bold]BODY FLUID and CSF:[/bold]
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Add body fluid (e.g., CSF, pleural, peritoneal) to a clean, leak proof sterile container and send at room temperature within 12 hours of collection.
Include a a copy of the body fluid cell count and differential.
An original cytospin preparation (preferably unstained) should be included when possible with CSF specimens for correlative morphological evaluation.
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[bold]BONE MARROW CORE BIOPSY AND FNA:[/bold]
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Submerge in RPMI tissue culture medium (for optimal cell viability) or sterile saline and transport at room temperature within 12 hours of collection.
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[bold]FRESH TISSUE:[/bold]
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Mince and submerge in RPMI tissue culture medium (for optimal cell viability) or sterile saline, refrigerate, and transport refrigerated within 12 hours of collection.
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[bold]BONE MARROW ASPIRATE:[/bold] 1-2 ml
[bold]BODY FLUIDS:[/bold] 20-50 ml
[bold]CSF:[/bold] 5-10 ml
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[bold]BONE MARROW ASPIRATE:[/bold] 1 ml
[bold]BODY FLUIDS:[/bold] 10 ml*
[bold]CSF:[/bold] 1 ml*
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* The volume of Body Fluids and CSF required is dependent on the cellularity of the specimen.