Test Overview
Test Methodology

Nephelometry

Test Usage

To aid in identification of various immunodeficiency states and the evaluation of immunoproliferative disorders (polyclonal vs. monoclonal). More specifically, the levels are used to diagnose and classify disorders of humoral immunity; diagnose and monitor therapy in myeloma, macroglobulinemia of Waldenstrom and heavy chain disease; evaluate lymphoproliferative diseases, including lymphoma; evaluate primary biliary cirrhosis and other autoallergic liver disease, particularly chronic active hepatitis; evaluate amyloidosis.

Reference Range *

IMMUNOGLOBULIN A: Cord blood (age <1 mos): 1 - 4 mg/dL, age 1 mos: 2 - 50 mg/dL, age 2-9 mos: 4 - 80 mg/dL, age 10-11 mos: 15 - 90 mg/dL, age 1-4 yrs: 15 - 160 mg/dL, age 5-11 yrs: 35 - 250 mg/dL, age 12-150 yrs: 40 - 350 mg/dL. IMMUNOGLOBULIN G: Cord blood (age <1 mos): 610 - 1540 mg/dL, age 1 mos: 240 - 870 mg/dL, age 2-5 mos: 170 - 670 mg/dL, age 6-9 mos: 210 - 870 mg/dL, age 10-11 mos: 280 - 1030 mg/dL, age 1 yr: 330 - 1160 mg/dL, age 2-3 yrs: 405 - 1160 mg/dL, age 4-5 yrs: 440 - 1190 mg/dL, age 6-150 yrs: 620 - 1520 mg/dL. IMMUNOGLOBULIN M: Cord blood (age <1 mos): 6 - 25 mg/dL, age 1 mos: 20 - 80 mg/dL, age 2-5 mos: 25 - 95 mg/dL, age 6-11 mos: 35 - 140 mg/dL, age 1-7 yrs: 40 - 190 mg/dL, age 8-11 yrs: 50 - 240 mg/dL, age 12-150 yrs: 50 - 370 mg/dL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

See individual assays

Test Details
Days Set Up
Monday - Friday
Analytic Time

8 hours

Soft Order Code
IGS
MiChart Code
Immunoglobulin Quantitation (IgG, IgA, IgM)
Synonyms
  • Globulins, Serum
  • IgG,A,M
  • IGS
  • Immunoglobulin G,A,M
  • Immunoglobulins
  • Quantitative Immunoglobulins
  • Serum Immunoglobulins
  • IMMUNOGLOBULIN QUANTITATION
  • IGA
  • IGG
  • IGM
  • IMMUNOGLOBULIN A
  • IMMUNOGLOBULIN G
  • IMMUNOGLOBULIN M
Laboratory
Chemical Pathology
Section
Immunopathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.
Store at 2-8°C up to 8 days.
Samples may be frozen at -20°C or below for up to 3 months if they are frozen within 24 hours after collection.

Alternate Specimen
Red top
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum
Additional Information

Total protein and protein electrophoresis are not part of the Immunoglobulin Quantitation and must be requested separately if needed. Polyclonal elevations are found in acute and chronic inflammation, drug induced cholestatic hepatitis, cirrhosis, biliary cirrhosis, chronic infections, subacute bacterial endocarditis, sarcoidosis, ulcerative colitis, intestinal obstruction, autoimmune diseases, and others. IgG elevation is seen in IgG myeloma and chronic active hepatitis. IgA elevation is seen in respiratory and gastrointestinal infections, IgA myeloma, malabsorption and diarrhea. IgM elevation is seen in viral infections, in Waldenstrom's macroglobulinemia, after numerous transfusions and in nephrotic syndrome. One or more immunoglobulins may be elevated in benign monoclonal gammopathy; these may not be clinically significant. One or more of the immunoglobulins may be decreased on a congenital basis. Acquired decreases are seen in relation to immunosuppressive therapy, lymphoma, leukemia, myeloma, macroglobulinemia, and excessive protein loss (nephrosis, renal disease, gastroenteropathies, cutaneous burns, ascites, eczema).

Billing
CPT Code
82784 x3
Fee Code
21986, 21987, 21988
Resources