Evaluation of blood-brain barrier integrity and detection of local CNS IgG synthesis.
CSF Albumin: 5-34 mg/dL; CSF IgG: 0-4.5 mg/dL; Serum Albumin (Adult): 3.5 - 4.9 g/dL; Serum IgG (Adult): 620-1520 mg/dL; IGG INDEX: 17-29 years: 0.32-0.60, 30-39 years: 0.34-0.59, 40-49 years: 0.36-0.56, 50-59 years: 0.33-0.57, 60-150 years: 0.34-0.58.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
- GI Index
- GIN IgG
- IgG Index
- IgG Synthesis Rate
- Index, IgG
- Multiple Sclerosis (MS)
- ALBUMIN - SERUM
- IMMUNOGLOBULIN G
- IMMUNOGLOBULIN G-CSF
- IGG INDEX RESULT
Both blood and CSF samples must be obtained on the same day. Collect blood in SST tube. Centrifuge and aliquot serum into a plastic vial. Refrigerate serum and CSF.
IgG Index = (CSF/Serum IgG ratio)/(CSF/Serum Albumin ratio). IgG Index may be increased in 75% of patients with multiple sclerosis (MS), in 69% with lupus cerebritis, in 33% with CNS infection, in 6-12% of other inflammatory disease, and in 3% of people with no clinical evidence of neurological disease. Oligoclonal bands will be present in 81% of MS patients and in less than 10% of patients with lupus cerebritis.