The level of CSF albumin is used as a reference to indicate whether an increase of the IgG is due to local secretion or to increased permeability of the blood capillaries. CSF IgG is frequently elevated in multiple sclerosis; elevations occur also in CNS syphilis, postvaccinial encephalitis, subacute sclerosing leukoencephalitis, and other primary inflammatory states of the CNS.
CSF IgG: 0-4.5 mg/dL; CSF Albumin: 5-34 mg/dL; CSF IgG/Albumin ratio: 0.02-0.20
Normal levels do not rule out multiple sclerosis.
- Albumin, CSF
- Cerebrospinal Fluid IgG
- CSF IgG and Albumin
- CSF Immunoglobulin and Albumin
- IgG and Alb, CSF
- IgG and Albumin, CSF
- Protein, CSF, IgG/A Ratio
- Spinal Fluid Immunoglobulin and Albumin
- IGG AND ALBUMIN - CSF
- ALB CSF
- ALBUMIN - CSF
- IMMUNOGLOBULIN G - CSF
Collect spinal fluid and refrigerate up to 1 week.
The CSF IgG/Albumin ratio is elevated in multiple sclerosis (MS), neurosyphilis, post vaccinial encephalitis, and subacute sclerosing leukoencephalitis. High normal values may indicate degenerative diseases such as cerebral or cerebellar atrophy, amyotrophic sclerosis or brain tumor. Normal levels can occur in incomplete obstruction of the spinal canal. Increase in albumin alone can be a result of a lesion in the choroid plexus or a blockage in the flow of CSF. Electrophoretic analysis of CSF protein may show oligoclonal `bands' in cases of MS but false positive patterns also occur (e.g., absence of absolute specificity). (See Oligoclonal Bands, CSF). Determination of myelin basic protein in CSF may be of use in diagnosis of MS or other active demyelinating processes. (See Myelin Basic Protein, CSF.)