Test Overview
Test Methodology

Nephelometry

Test Usage

The level of CSF albumin is used as a reference to indicate whether an increase of the IgG is due to local secretion or to increased permeability of the blood capillaries. CSF IgG is frequently elevated in multiple sclerosis; elevations occur also in CNS syphilis, postvaccinial encephalitis, subacute sclerosing leukoencephalitis, and other primary inflammatory states of the CNS.

Reference Range *

CSF IgG: 0-4.5 mg/dL; CSF Albumin: 5-34 mg/dL; CSF IgG/Albumin ratio: 0.02-0.20

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Normal levels do not rule out multiple sclerosis.

Test Details
Days Set Up
Tuesday, Friday
Analytic Time

8 hours

Soft Order Code
GALB
MiChart Code
IgG and Albumin, CSF
Synonyms
  • Albumin, CSF
  • Cerebrospinal Fluid IgG
  • CSF IgG and Albumin
  • CSF Immunoglobulin and Albumin
  • IGCSF
  • IgG and Alb, CSF
  • IgG and Albumin, CSF
  • Protein, CSF, IgG/A Ratio
  • Spinal Fluid Immunoglobulin and Albumin
  • IGG AND ALBUMIN - CSF
  • ALB CSF
  • ALCSF
  • ALBUMIN - CSF
  • IMMUNOGLOBULIN G - CSF
Laboratory
Chemical Pathology
Section
Immunopathology
Specimen Requirements
Collection Instructions

Collect spinal fluid and refrigerate up to 1 week.

Normal Volume
1.0 mL CSF
Minimum Volume
0.5 mL CSF
Additional Information

The CSF IgG/Albumin ratio is elevated in multiple sclerosis (MS), neurosyphilis, post vaccinial encephalitis, and subacute sclerosing leukoencephalitis. High normal values may indicate degenerative diseases such as cerebral or cerebellar atrophy, amyotrophic sclerosis or brain tumor. Normal levels can occur in incomplete obstruction of the spinal canal. Increase in albumin alone can be a result of a lesion in the choroid plexus or a blockage in the flow of CSF. Electrophoretic analysis of CSF protein may show oligoclonal `bands' in cases of MS but false positive patterns also occur (e.g., absence of absolute specificity). (See Oligoclonal Bands, CSF). Determination of myelin basic protein in CSF may be of use in diagnosis of MS or other active demyelinating processes. (See Myelin Basic Protein, CSF.)

Billing
CPT Code
82784 IgG, 82402 Albumin CSF
Fee Code
21987, 22202
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