Test Overview
Test Methodology


Test Usage

Aids in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom's macroglobulinemia, amyloidosis, light chain deposition disease and connective tissue diseases such as systemic lupus erythematosus. Elevated serum levels of monoclonal free light chains are associated with malignant plasma cell proliferation (eg. multiple myeloma), primary amyloidosis and light chain deposition disease. Raised serum levels of polyclonal free light chains may be associated with automimmune diseases such as systemic lupus erythematosus.

Reference Range *

Kappa Free Light Chain: 0.33 - 1.94 mg/dL, Lambda Free Light Chain: 0.57 - 2.63 mg/dL, Kappa/Lambda FLC Ratio: 0.26 - 1.65.

Test Limitations

Elevated kappa and lambda FLC may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (e.g., FLC K/L ratio) must be demonstrated for diagnostic purposes.

Test Details
Days Set Up
Monday - Friday
Soft Order Code
MiChart Code
Immunoglobulin Free Light Chains, Blood
  • Freelite
  • IFLC
  • Kappa Free Light Chain
  • Lambda Free Light Chain
  • KFLC
  • K/LFLC
  • LFLC
  • Serum Free Lightchain
Chemical Pathology
Specimen Requirements
Collection Instructions

Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Alternate Specimen
Red top tube.
Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.3 mL serum
CPT Code
83883 x2
Fee Code
33300 KFLC, 36100 LFLC
44793-8 IFLC, 36916-5 KFLC, 33944-0 LFLC, 15189-4 K/LFLC
NY State Approved