Aids in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom's macroglobulinemia, amyloidosis, light chain deposition disease and connective tissue diseases such as systemic lupus erythematosus. Elevated serum levels of monoclonal free light chains are associated with malignant plasma cell proliferation (eg. multiple myeloma), primary amyloidosis and light chain deposition disease. Raised serum levels of polyclonal free light chains may be associated with automimmune diseases such as systemic lupus erythematosus.
Kappa Free Light Chain: 0.33 - 1.94 mg/dL, Lambda Free Light Chain: 0.57 - 2.63 mg/dL, Kappa/Lambda FLC Ratio: 0.26 - 1.65.
Elevated kappa and lambda FLC may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (e.g., FLC K/L ratio) must be demonstrated for diagnostic purposes.
- Kappa Free Light Chain
- Lambda Free Light Chain
- Serum Free Lightchain
Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.