The IPF (Immature Platelet Fraction) will be reflexed on any platelet that is below 150 K/uL.
The IPF is an early indicator of platelet production and typically elevated in disorders of platelet destruction, such as ITP, TTP, and DIC. It is also an early indicator of bone marrow recovery in post-chemotherapy and stem cell transplant patients. A decreased IPF is indicative of decreased platelet production in the bone marrow.
Normal Range: 1.0-7.0 Percent
STAT: 1 hour; Routine: 4 - 8 hours
Collect specimen in a lavender top EDTA K2 vacutainer tube or EDTA K2 microtainer tube. Send intact within 24 hours of collection if stored at room temperature or within 48 hours if stored refrigerated.
IPF is not orderable in MiChart. Test will reflex on patients with platelets <150 K/uL.
An automated parameter, the Immature Platelet Fraction percent (IPF%) indicates the ratio of immature platelets to the total number of platelets in a patient’s peripheral blood. These immature platelets, newly released from the bone marrow, contain increased amounts of cytoplasmic RNA which allows them to be differentiated from mature platelets using a fluorescence staining method on an automated analyzer. The Sysmex® XN- and XE-Series Automated Hematology Analyzers are capable of reporting the IPF% result as a direct cellular measurement of thrombopoiesis, which can be used with other available clinical information to help physicians determine the pathophysiological mechanism of thrombocytopenia.