Immature Platelet Fraction (IPF)

Test Overview

Test Methodology

Sysmex XN9000

Test Usage

The IPF (Immature Platelet Fraction) will be reflexed on any platelet that is below 150 K/uL.
The IPF is an early indicator of platelet production and typically elevated in disorders of platelet destruction, such as ITP, TTP, and DIC. It is also an early indicator of bone marrow recovery in post-chemotherapy and stem cell transplant patients. A decreased IPF is indicative of decreased platelet production in the bone marrow.

Reference Range*

Normal Range: 1.0-7.0 Percent

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details

Days Test Performed

Daily, 24 hours

Analytic Time

STAT: 1 hour; Routine: 4 - 8 hours

Laboratory

Hematopathology

Looking to Order a Test?

We’ve provided helpful links to make ordering easy.

Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

Test FAQ

Visit our provider FAQ and learn about common questions to ordering tests.

Specimen Requirements

Offsite Collection Instructions

Collect specimen in a lavender top EDTA K2 vacutainer tube or EDTA K2 microtainer tube. Send intact within 24 hours of collection if stored at room temperature or within 48 hours if stored refrigerated.

Container

Normal Volume

3 ml EDTA K2 whole blood in vacutainer tube or 500 µl EDTA K2 whole blood in microtainer tube

Minimum Volume

1 ml EDTA K2 whole blood in vacutainer tube or 300 µl EDTA K2 whole blood in microtainer tube

Additional Information

IPF is not orderable in MiChart. Test will reflex on patients with platelets <150 K/uL.
An automated parameter, the Immature Platelet Fraction percent (IPF%) indicates the ratio of immature platelets to the total number of platelets in a patient’s peripheral blood. These immature platelets, newly released from the bone marrow, contain increased amounts of cytoplasmic RNA which allows them to be differentiated from mature platelets using a fluorescence staining method on an automated analyzer. The Sysmex® XN- and XE-Series Automated Hematology Analyzers are capable of reporting the IPF% result as a direct cellular measurement of thrombopoiesis, which can be used with other available clinical information to help physicians determine the pathophysiological mechanism of thrombocytopenia.