Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate imipramine toxicity.

Reference Range *

Therapeutic: 150 - 250 ng/mL; Toxic: > 500 ng/mL (sum of Imipramine and Desipramine).

Test Limitations

Other tricyclic antidepressants may interfere when administered concomitantly.

Test Details
Days Set Up
Thursday
Analytic Time

4 hours

Soft Order Code
IMPN
MiChart Code
Imipramine and Desipramine Level
Synonyms
  • Imovate
  • Tofranil
  • Tricyclics, Imipramine and Desipramine
  • IMIPRAMINE/DESIPRAMINE
  • DESI2
  • IMIP
  • DESIPRAMINE
  • IMIPRAMINE
  • DESIPRAMINE RESULT
  • IMIPRAMINE LEVEL
Laboratory
Chemical Pathology
Section
Drug Analysis
Specimen Requirements
Collection Instructions

Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.

Alternate Specimen
Lavender top (EDTA plasma) [11/09]
Rejection Criteria
SST or PST tube not acceptable.
Yellow Top Tube
Red Top Tube
Normal Volume
1 mL serum or plasma
Minimum Volume
0.7 mL serum or plasma
Additional Information

Test includes Imipramine and its active metabolite, Desipramine.

Billing
CPT Code
80335
Fee Code
KA005
LOINC
Z13-3
NY State Approved
No