Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Monitor therapeutic drug levels; monitor patient compliance; evaluate imipramine toxicity.
Therapeutic: 150 - 250 ng/mL; Toxic: > 500 ng/mL (sum of Imipramine and Desipramine).
Other tricyclic antidepressants may interfere when administered concomitantly.
- Tricyclics, Imipramine and Desipramine
- DESIPRAMINE RESULT
- IMIPRAMINE LEVEL
Collect blood in a red top or green top tube; do not use SST tube. Centrifuge, aliquot serum or plasma into plastic vial as soon as possible and refrigerate.
Test includes Imipramine and its active metabolite, Desipramine.