Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Monitor therapeutic drug levels; monitor patient compliance; evaluate imipramine toxicity.

Reference Range *

Imipramine and Desipramine: Therapeutic: 175 - 300 ng/mL. Desipramine only: Therapeutic: 100 - 300 ng/mL. Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Tuesday, Thursday, Sunday
Analytic Time

3 - 5 days

Soft Order Code
IMIPR
MiChart Code
Imipramine and Desipramine Level
Synonyms
  • Imovate
  • Tofranil
  • Tricyclics, Imipramine and Desipramine
Laboratory
Sendout
Reference Laboratory
Mayo IMIPR
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect blood in a red top tube immediately before next scheduled dose (minimum 12 hours after last dose); do not use SST tube. Centrifuge, aliquot serum into plastic vial within 2 hours of colleciton, and refrigerate.

Normal Volume
1 mL serum
Minimum Volume
0.25 mL serum
Rejection Criteria
SST or PST tube not acceptable.
Additional Information

Test includes Imipramine and its active metabolite, Desipramine. Test sent to Mayo Clinic Laboratories.

Billing
CPT Code
80335
Fee Code
AB139
LOINC
43123-9
NY State Approved
No