IHG/BCL2 t(14;18) by FISH
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Fluorescence In Situ Hybridization (FISH)
This test detects the IGH/BCL2 t(14;18)(q32;q21) translocation via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue specimens. FISH is performed using a dual-color dual-fusion probe set (Abbott Molecular) to qualitatively assess for the presence of the IGH/BCL2 translocation that occurs in most follicular lymphomas (FL) and a subset of diffuse large B-cell lymphomas (DLBCL). Testing for the IGH/BCL2 translocation may aid in the diagnosis of these tumors.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
A formalin-fixed, paraffin-embedded tissue block containing sufficient neoplastic cells is preferred. Unstained slides (3, 4-micron slides) with associated H&E stained slide are also acceptable. Decalcified tissue or other fixatives will be accepted and the assay attempted, however these may result in failed testing due to degraded nucleic acid. Both blocks and slides should be stored at room temperature.