Test Overview
Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Evaluation of suspected insulinoma characterized by hypoglycemia and increased plasma insulin concentration. Detecting drugs that stimulate insulin secretion.

Reference Range *

Negative. Threshold cut off levels: Acetohexamide 1000 ng/mL; Chlorpropamide 1000 ng/mL; Tolazamide 20 ng/mL; Tolbutamide 50 ng/mL; Glimepiride 20 ng/mL; Glipizide 3 ng/mL; Glyburide 3 ng/mL; Repaglinide 3 ng/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Proper interpretation requires that the blood specimen be drawn during or close to the time of a hypoglycemic episode. Drugs will not be detected (and are not likely to be present) if blood is drawn when blood glucose is normal in nondiabetic patients. This test is not intended for therapeutic drug monitoring.

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

2 - 8 days

Soft Order Code
MiChart Code
Hypoglycemic Agent Screen
  • Sulfonylurea Hypoglycemic Serum
  • Hypoglycemic Agent Scrn, S
Reference Laboratory
Mayo HYPOG (82439)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube; do not use SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.

Normal Volume
3 mL serum
Minimum Volume
0.5 mL serum
Rejection Criteria
SST tube not acceptable.
Additional Information

Test sent to Mayo Medical Laboratories.

CPT Code
Fee Code