Test Overview
Test Methodology

Liquid chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Hydroxychloroquine is an antimalarial drug used to treat or prevent malaria. It is highly effective against erythrocytic forms of Plasmodium, but not effective against exoerythrocytic forms of parasites. Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus.

Reference Range *

For Rheumatologists: Per the Mok paper: https://www-ncbi-nlm-nih-gov.proxy.lib.umich.edu/pubmed/30014357
<10 (total noncompliance), 10–500 (subtherapeutic), and >500 ng/ml (therapeutic)

Mayo validated values:
For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.

For systemic lupus erythematosus, proposed blood target concentrations should be 1,000 ng/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Analytic Time

3 - 10 days

Soft Order Code
Reference Laboratory
Mayo (HCQ)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube (no SST), immediately before next scheduled dose. Spin and aliquot within 2 hours of collection. Send to Specimen Processing refrigerated.

Normal Volume
1 mL
Minimum Volume
0.5 mL
CPT Code
Fee Code