Liquid chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Hydroxychloroquine is an antimalarial drug used to treat or prevent malaria. It is highly effective against erythrocytic forms of Plasmodium, but not effective against exoerythrocytic forms of parasites. Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus.
For Rheumatologists: Per the Mok paper: https://www-ncbi-nlm-nih-gov.proxy.lib.umich.edu/pubmed/30014357
<10 (total noncompliance), 10–500 (subtherapeutic), and >500 ng/ml (therapeutic)
Mayo validated values:
For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.
For systemic lupus erythematosus, proposed blood target concentrations should be 1,000 ng/mL.
3 - 10 days
Collect specimen in a red top tube (no SST), immediately before next scheduled dose. Spin and aliquot within 2 hours of collection. Send to Specimen Processing refrigerated.