Days Set Up
Analytic Time

3 - 10 days

Soft Order Code

Test Updated:


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Find a Requisition

All specimens should be accompanied by a requisition.

Submitting Specimens

Learn about how to properly label and where to ship specimens.

Order Kits and Supplies

MLabs provides all the supplies necessary for the collection of specimens.

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Test Overview

Test Methodology

Liquid chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Hydroxychloroquine is an antimalarial drug used to treat or prevent malaria. It is highly effective against erythrocytic forms of Plasmodium, but not effective against exoerythrocytic forms of parasites. Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus.

Reference Range

For Rheumatologists: Per the Mok paper:
<10 (total noncompliance), 10–500 (subtherapeutic), and >500 ng/ml (therapeutic)

Mayo validated values:
For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.

For systemic lupus erythematosus, proposed blood target concentrations should be 1,000 ng/mL.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Specimen Requirements

Collection Offsite

Collect specimen in a red top tube (no SST), immediately before next scheduled dose. Spin and aliquot within 2 hours of collection. Send to Specimen Processing refrigerated.

Red Top Tube
Normal Volume
1 mL
Minimum Volume
0.5 mL

Billing Information

CPT Code
Pro Fee Code

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Our High Standard

Quality that sets us apart

As the reference laboratory division of Michigan Medicine's Department of Pathology, MLabs shares the institution's commitment to applying established quality principles to clinical laboratory testing. Like other large organizations in complex, consequential fields, we rely on an established approach to monitor quality throughout the testing process.