Test Overview
Test Methodology

Liquid chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Hydroxychloroquine is an antimalarial drug used to treat or prevent malaria. It is highly effective against erythrocytic forms of Plasmodium, but not effective against exoerythrocytic forms of parasites. Hydroxychloroquine is also used to treat symptoms of acute or chronic rheumatoid arthritis and lupus erythematosus.

Reference Range *

For Rheumatologists: Per the Mok paper: https://www-ncbi-nlm-nih-gov.proxy.lib.umich.edu/pubmed/30014357
<10 (total noncompliance), 10–500 (subtherapeutic), and >500 ng/ml (therapeutic)

Mayo validated values:
For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.

For systemic lupus erythematosus, proposed blood target concentrations should be 1,000 ng/mL.

Test Details
Days Set Up
Wednesday
Analytic Time

3 - 10 days

Soft Order Code
HCQ
Laboratory
Sendout
Reference Laboratory
Mayo (HCQ)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in a red top tube (no SST), immediately before next scheduled dose. Spin and aliquot within 2 hours of collection. Send to Specimen Processing refrigerated.

Red Top Tube
Normal Volume
1 mL
Minimum Volume
0.5 mL
Billing
CPT Code
80375
Fee Code
AA453
NY State Approved
No