Test Overview

Test Methodology


Test Usage

The presence of human anti-mouse antibody (HAMA) has been associated with patients receiving injections of murine monoclonal antibody (MAb) for diagnostics and/or theraputic purposes. HAMA produced in response to monoclonal antibody therapy may interfere with theraputic efficacy. Therefore, it is recommended that baseline HAMA levels are determined prior to the initiation of therapy with murine-derived proteins.

Reference Range*

<74 ng/mL

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

HAMA may be detected in a small percentage of the general population, and usually represent heterophilic antibodies or dietary exposure to murine proteins.

Test Details

Days Test Performed


Analytic Time

7 - 15 days

Soft Order Code





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Laboratory Reference

Quest Valencia 1468

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in a red top tube. Centrifuge, aliquot serum into a plastic vial and freeze.

Rejection Criteria

SST is not acceptable


Red Top Tube

Normal Volume

1 mL serum

Minimum Volume

0.5 mL serum

Additional Information

Quest Diagnostics Nichols Institute of Valencia.

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Fee Codes

CPT Code


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