Test Overview
Test Methodology

Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)

Test Usage

Confirm diagnosis of neuroblastoma; monitor response to therapy.

Reference Range *

24 Hour Urine - HVA
0-1 years: <4.0 mg/24 hours
1-3 years: <7.0 mg/24 hours
3-10 years: <10.0 mg/24 hours
>10 years: <12.0 mg/24 hours

Random Urine - HVA / Creatinine Ratio
0-1 years: <35 mg/gm Creatinine
1-3 years: <25 mg/gm Creatinine
3-10 years: <15 mg/gm Creatinine

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday, Thursday
Analytic Time

8 hours

Soft Order Code
HVA/HVAR
Synonyms
    Laboratory
    Chemical Pathology
    Section
    Drug Analysis
    Specimen Requirements
    Collection Instructions

    Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Random samples will be accepted on children less than 10 years old, in which case the HVAR test code must be ordered instead of the HVA test code.

    Alternate Specimen
    May be collected in plain (no preservative) container and acid added at the end of collection. It is preferred to have acid added as soon as possible at the client site, mixed, and an aliquot sent. A non-acidified aliquot may also be sent. [rev 9/08] Random samples will be accepted on children less than 10 years old, in which case the HVAR test code must be ordered instead of the HVA test code.
    Normal Volume
    10 mL aliquot of 24 hour urine collection
    Minimum Volume
    10 mL aliquot of 24 hour urine collection
    Additional Information

    Tested using a laboratory developed assay performed on a Waters liquid chromatography tandem mass spectrometry (LC-MS/MS) system. Results determined from different manufacturers and/or methods may not be comparable.

    Billing
    CPT Code
    83150
    Fee Code
    KA024
    NY State Approved
    No