Test Overview
Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS)
Confirm diagnosis of neuroblastoma; monitor response to therapy.
24 Hour Urine - HVA
0-1 years: <4.0 mg/24 hours
1-3 years: <7.0 mg/24 hours
3-10 years: <10.0 mg/24 hours
>10 years: <12.0 mg/24 hours
Random Urine - HVA / Creatinine Ratio
0-1 years: <35 mg/gm Creatinine
1-3 years: <25 mg/gm Creatinine
3-10 years: <15 mg/gm Creatinine
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Test Details
8 hours
Specimen Requirements
Collect 24 hour urine specimen. Add 25 mL of 50% glacial acetic acid (15 mL for pediatric patients) to container prior to start of collection. Following collection, mix well, measure 24 hour urine volume, aliquot 10 mL into a plastic urine container and refrigerate. Record total 24 hour urine volume and collection dates/times on request form. Specimens with no preservative are also acceptable: add 50% glacial acetic acid to container following collection, mix well and send 10 mL aliquot (preferred); alternatively a non-acidified aliquot will be accepted. Random samples will be accepted on children less than 10 years old, in which case the HVAR test code must be ordered instead of the HVA test code.
Additional Information
Tested using a laboratory developed assay performed on a Waters liquid chromatography tandem mass spectrometry (LC-MS/MS) system. Results determined from different manufacturers and/or methods may not be comparable.