Assessment of risk for occlusive vascular disease, obstetric complications (recurrent spontaneous abortion, gross placental infarction), and neural tube defects (hyperhomocysteinemia). Patients taking methotrexate, nicotinic acid, theophylline, nitrous oxide or L-Dopa may have falsely elevated Homocysteine levels. S-adenosyl-methionine is an antidepressant that is structurally similar to S-adenohomocysteine. Individuals taking this drug may show elevated levels of Homocysteine.
5 - 15 mcmol/L. The population determined reference interval for homocysteine is 5-15uM. However, studies have shown a gradual increase in risk for atherosclerosis as homocysteine levels increase above 11 uM.
Homocysteine levels may be affected by gross hemolysis or lipemia.
Collect blood in a lavender top tube from a fasting patient. Centrifuge and aliquot plasma into plastic vial within 30 minutes of collection. Freeze (preferred) or refrigerate up to 2 days; specimens stored at room temperature are unacceptable.
Fasting specimen preferred. Place on ice immediately and deliver to lab or aliquot within 30 minutes.