Test Overview
Test Methodology

Chemiluminescent Assay

Test Usage

Assessment of risk for occlusive vascular disease, obstetric complications (recurrent spontaneous abortion, gross placental infarction), and neural tube defects (hyperhomocysteinemia). Patients taking methotrexate, nicotinic acid, theophylline, nitrous oxide or L-Dopa may have falsely elevated Homocysteine levels. S-adenosyl-methionine is an antidepressant that is structurally similar to S-adenohomocysteine. Individuals taking this drug may show elevated levels of Homocysteine.

Reference Range *

4 - 14 mcmol/L. The population determined reference interval for homocysteine is 4-14uM. However, studies have shown a gradual increase in risk for atherosclerosis as homocysteine levels increase above 11 uM.

Test Limitations

Homocysteine levels may be affected by gross hemolysis or lipemia.

Test Details
Days Set Up
Daily, 24 hours
Analytic Time

4 hours

Soft Order Code
HCY
MiChart Code
Homocysteine
Synonyms
  • HOMOCYSTEINE
  • HCY
Laboratory
Chemical Pathology
Section
Automation
Specimen Requirements
Collection Instructions

Collect blood in a lavender top tube from a fasting patient. Centrifuge and aliquot plasma into plastic vial within 30 minutes of collection. Freeze (preferred) or refrigerate up to 2 days; specimens stored at room temperature are unacceptable.

Special Handling

Fasting specimen preferred. Place on ice immediately and deliver to lab or aliquot within 30 minutes.

Alternate Specimen
Green Top Tube (heparinized plasma)
Contraindications
This test is not indicated for inpatient evaluation of acute thrombosis.
Normal Volume
2 mL EDTA whole blood or 1 mL EDTA plasma
Minimum Volume
1 mL EDTA whole blood or 0.5 mL EDTA plasma
Billing
CPT Code
83090
Fee Code
20919
LOINC
2428-1
NY State Approved
No