Test Overview
Test Methodology

Molecular Typing (SSOP)

Test Usage

Narcolepsy is a chronic, debilitating sleep disorder. One of the most important associated genetic factors is the HLA-DQB1*06:02 allele on the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Between 85 and 95% of narcolepsy patients with cataplexy carry this haplotype. Persons homozygous for HLA-DQB1*06:02 carry a greater risk than heterozygous persons. The detection of HLA-DQB1*06:02 typing is useful as an aid to diagnosis in patients with cataplexy.

Reference Range *

Interpretive report will indicate presence or absence of HLA-DQB1*0602.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

Soft Order Code
NARC
MiChart Code
Disease Assoc - NARCOLEPSY (HLA-DQB1*0602)
Synonyms
  • Narcolepsy - HLA DQB1*0602
  • HLA DQB1*0602
  • DQB1*0602 Antigen
  • TTYPE
  • TISSUE TYPING
  • HLA REPORT
  • NARC
  • Narcolepsy, HLA
  • HLA Class II One Locus (High Resolution)
Laboratory
Histocompatibility/Immunogenetics
Section
Histocompatibility
Specimen Requirements
Collection

Collect specimen in sufficient yellow top (ACD) solution A or EDTA tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.

Alternate Specimen
Yellow top ACD Solution B, Green top tube (sodium or lithium heparin) or Lavender top tubes (EDTA).
Normal Volume
10 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Minimum Volume
5 mL ACD (solution A ) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Billing
CPT Code
81376
Fee Code
37925
NY State Approved
No
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