Test Overview
Test Methodology

Molecular Typing (SSOP)

Test Usage

A severe or even fatal skin reaction has been associated with carbamazepine therapy. Carbamazepine hypersensitivity is significantly more common in patients with HLA-B*1502. This allele is frequent in patients with ancestry from Asia, including South Asian Indians. Patients with ancestry or from these areas should be screened for the HLA-B*1502 allele before treatment with carbamazepine. Treatment with carbamazepine is not recommended for HLA-B*1502 positive patients.

Reference Range *

Interpretive report will indicate presence or absence of HLA-B*1502.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

Soft Order Code
CARB
MiChart Code
Disease Assoc - CARBAMAZEPINE HYPERSENSITIVITY (HLA-B*1502)
Synonyms
  • HLA Class I One Locus (High Resolution)
  • HLA B*1502
  • B1502 Antigen
  • Carbamazepine Sensitivity
  • HLA REPORT
  • TTYPE
  • TISSUE TYPING
  • CARB
Laboratory
Histocompatibility/Immunogenetics
Section
Histocompatibility
Specimen Requirements
Collection

Collect specimen in sufficient yellow top (ACD) solution A or EDTA tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.

Alternate Specimen
Yellow top ACD Solution B, Green top tube (sodium or lithium heparin), lavender top EDTA
Normal Volume
10 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Minimum Volume
5 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Billing
CPT Code
81373
Fee Code
37924
Resources