Update Type: Miscellaneous
Test Updated: 04/16/2025
Test Overview
Test Methodology

Molecular Typing (SSOP)

Test Usage

The presence of HLA-B27 may help to confirm the diagnosis and aid in treatment of Ankylosing Spondylitis. There is a strong association with the HLA class I molecule HLA-B27, found in 90% of patients with Ankylosing Spondylitis. This association is one of the strongest genetic associations with a common disease, although the mechanism of action remains undefined.

Reference Range *

Interpretive report will indicate presence or absence of HLA-B27.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

Ankylosing Spondylitis cannot be diagnosed or ruled out by this test.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

Soft Order Code
ANKYL
MiChart Code
Disease Assoc - ANKYLOSING SPONDYLISTIS (HLA-B27)
Synonyms
  • HLA Class I One Locus (Low Resolution)
  • B27 Antigen
  • HLA B-27
  • Ankylosing Spondylitis - HLA B27
Laboratory
Histocompatibility/Immunogenetics
Section
Histocompatibility
Specimen Requirements
Collection

Collect specimen in sufficient yellow top (ACD) solution A tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.

Alternate Specimen
Lavender EDTA
Normal Volume
10 mL ACD (solution A) whole blood; additional specimen may be required for patients with extremely low white cell counts.
Minimum Volume
5 mL ACD (solution A) whole blood; additional specimen may be required for patients with extremely low white cell counts.
Additional Information

Ankylosing Spondylitis (AS) is one of the major forms of chronic inflammatory arthritis and is the classical example of the spondyloarthropathies, a group of chronic autoimmune joint diseases.

Billing
CPT Code
81373
Fee Code
37924
NY State Approved
No