Test Overview
Test Methodology

Molecular Typing (SSOP)

Test Usage

Abacavir hypersensitivity has been shown to be associated with HLA-B*5701. The FDA has issued a recommendation that all patients should be screened for the HLA-B*5701 allele before starting or restarting treatment with Abacavir (Ziagen) or Abacavir-containing medications. Treatment with an Abacavir-containing regimen is not recommended for HLA-B*5701 positive patients.

Reference Range *

Interpretive report will indicate presence or absence of HLA-B*5701.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Details
Days Set Up
Monday - Friday, 8:00am - 4:30pm
Analytic Time

5 days

Soft Order Code
ABAC
MiChart Code
Disease Assoc - ABACAVIR HYPERSENSITIVITY (HLA-B*5701)
Synonyms
  • HLA Class I One Locus (High Resolution)
  • TISSUE TYPING
  • TTYPE
  • B5701 Antigen
  • Abacavir Sensitivity
  • HLA B*5701
  • HLA REPORT
  • ABAC
Laboratory
Histocompatibility/Immunogenetics
Section
Histocompatibility
Specimen Requirements
Collection

Collect specimen in sufficient yellow top (ACD) solution A tubes early in the day. Send intact specimen at room temperature. Do not refrigerate or freeze.

Alternate Specimen
Yellow top ACD Solution B, Green top tube (sodium or lithium heparin).
Normal Volume
10 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Minimum Volume
5 mL ACD (solution A) or EDTA whole blood; additional specimen may be required for patients with extremely low white cell counts.
Additional Information

Serious and sometimes fatal hypersensitivity reactions caused by Abacavir therapy are significantly more common in patients with the HLA-B*5701 allele. Abacavir hypersensitivity is a multi-organ syndrome characterized by two or more clinical signs or symptoms that can include fever, rash, gastrointestinal symptoms, respiratory symptoms and constitutional symptoms. Clinicians should discontinue Abacavir therapy permanently if the patient becomes seriously ill and hypersensitivity cannot be ruled out, regardless of HLA-B*5701 status.

Billing
CPT Code
81373
Fee Code
37924
Resources