Test Overview
Test Methodology

Enzyme Immunoassay

Test Usage

Testing for autoantibodies to total histones is useful for evaluating patients suspected of having drug-induced lupus erythematosus (LE). Such patients will usually have a positive test for histone autoantibodies and a negative test for autoantibodies to double stranded DNA (ds-DNA). Patients with idiopathic LE have positive tests for both types of
autoantibodies.

Reference Range *

Negative

Test Details
Days Set Up
Monday, Wednesday, Friday
Analytic Time

1 - 4 days

Soft Order Code
HIS
MiChart Code
Histone Antibody
Synonyms
  • Anti-Histone Antibody
  • Autoantibodies to Histone
  • Extractable Nuclear Antibody, Histone
  • HIS
  • HISTONE ANTIBODY
Laboratory
Sendout
Reference Laboratory
Mayo HIS (80944)
Section
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in an SST or red top tube. Centrifuge, aliquot serum into a plastic vial and refrigerate.

Yellow Top Tube
Normal Volume
0.5 mL serum
Minimum Volume
0.45 mL serum
Additional Information

Test sent to Mayo Medical Laboratories.

Billing
CPT Code
83516
Fee Code
31529
LOINC
43231-0
NY State Approved
No