HHV-8 is also known as Kaposi Sarcoma, a malignancy of the skin. HHV-8 is not ubiquitous like most other herpesviruses. The distribution of HHV-8 is related to a combination of geographic factors and behavioral risk factors. Primary infection of HHV-8 in immunocompromised children is associated with fever and maculopapular rash. Numerous studies have documented the risk of developing KS among organ transplant recipients and patients taking immunesuppressive drugs.