Optical determination of clotting time after addition of hexagonal phospholipid reagent.
Detection of phospholipid antibody (lupus anticoagulant) in plasma.
Negative or <= 6.0
- Thromboplastin Inhibition test TTI
- Staclot LA
- Lupus Anticoagulant
- Hexagonal LA
- Hexagonal phospholipid neut
- Phospholipid Antibody (Lupus Anticoagulant)
Collect specimen in a blue top (citrate 3.2%) tube. Mix by inversion. Specimen should arrive at lab within 3 hours of collection; transport at room temperature. Alternatively, centrifuge, aliquot plasma into a plastic tube, and freeze the specimen within 4 hours of collection. Transport frozen specimen on dry ice. Collection of the blood through lines that have been previously flushed with heparin should be avoided. If the blood must be drawn through a VAD (vascular access device), the line should be flushed with 5 mL of saline and the first 5 mL of blood or six dead space volumes of the VAD discarded.
Phospholipid antibodies are associated with a variety of clinical conditions, including thrombosis, throbocytopenia, and fetal loss. They are also present in individuals with SLE, rheumatoid arthritis, and other autoimmune diseases. Transient development of lupus anticoagulants is common with viral infections, and certain drug therapies.