Test Overview
Test Methodology


Test Usage

Diagnosis of acute or recent (<6 months) hepatitis E infection.

Reference Range *

Negative. Borderline results may be seen in: 1) acute hepatitis E infection with rising level of anti-hepatitis E virus (HEV) IgM; 2) recent hepatitis E infection with declining level of anti-HEV IgM; or 3) cross-reactivity with nonspecific antibodies (ie, false-positive results).

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

A negative test result does not exclude the presence of recent hepatitis E infection, especially in immunocompromised patients. Repeat testing of serum for anti-HEV IgM in 2 to 4 weeks may be necessary for diagnosis of acute in such patients.

Test Details
Days Set Up
Tuesday, Thursday
Analytic Time

5 - 9 days

Soft Order Code
MiChart Code
Hepatitis E Antibody, IgM
  • Hepatitis E, IgM
Reference Laboratory
Mayo HEVM (86212)
Special Testing
Specimen Requirements
Collection Instructions

Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.

Normal Volume
0.5 mL serum
Minimum Volume
0.5 mL serum
Additional Information

Test sent to Mayo Medical Laboratories. If hepatitis E virus (HEV) IgM antibody screen is reactive or borderline, HEV IgM antibody confirmation (HEVML) will be performed at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.

CPT Code
Fee Code