Test Overview

Test Methodology


Test Usage

Diagnosis of past exposure to hepatitis E virus.

Reference Range*

Negative. Borderline results may be seen in: 1) acute or recent hepatitis E infection with rising level of anti-HEV IgG, or 2) cross-reactivity with nonspecific antibodies (ie, false-positive results). Repeat testing of serum for anti-HEV IgG in 4 to 6 weeks is recommended to determine the definitive HEV infection status.

* Reference ranges may change over time. Please refer to the original patient report when evaluating results.

Test Limitations

A negative test result does not exclude the presence of recent hepatitis E infection (<2 month duration), especially in immunocompromised patients. Repeat testing for anti-hepatitis E virus (HEV) IgM and anti-HEV IgG in 1 to 2 months is necessary for diagnosis of recent hepatitis E.

Test Details

Days Test Performed

Wednesday, Friday

Analytic Time

5 - 9 days

Soft Order Code


MiChart Code

Hepatitis E Antibody, IgG



Hepatitis E, IgE

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Laboratory Reference

Mayo HEVG (86211)

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Specimen Requirements

Offsite Collection Instructions

Collect specimen in an SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.


Yellow Top Tube

Normal Volume

0.5 mL serum

Minimum Volume

0.1 mL serum

Additional Information

Test sent to Mayo Medical Laboratories.

Billing Information

Fee Codes

CPT Code




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