Test Overview
High Pressure Liquid Chromatography (HPLC)
Evaluate distribution of hemoglobins.
HGBN-A1: 96.0 - 98.0% of total hemoglobin; HGBN-A2: 2.3 - 3.4% of total hemoglobin; HGBN-F, 0-1 month: 46.0 - 81.0% of total hemoglobin; HGBN-F, 1-4 months: 9.4 - 61.0% of total hemoglobin; HGBN-F, 4-12 months: 1.3 - 22.0% of total hemoglobin; HGBN-F, 1 - 150 years: less than or equal to 2% of total hemoglobin. There are no established reference ranges for HGBN-C and HGBN-S. Pathologist interpretation of abnormal results provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Numerous transfusions prior to HGBE testing may affect results. HGBE testing on newborns may be affected by high levels of fetal hemoglobin.
Test Details
24 hours
- Hemoglobin Electrophoresis
- Hemoglobin Electrophoresis Replacement Assay
- Hemoglobin Evaluation
- Hemoglobinopathy Evaluation
- Hgb A1
- Hgb A2
- Hgb C
- Hgb F
- Hgb S
- Beta Thalassemia Screen
- HEMOGLOBIN ELECTORPHORESIS
- HGB EVAL
- Hemoglobin A1
- Hemoglobin A2
- Hemoglobin C
- HEMOGLOBIN INTERPRETATION
- Hemoglobin F
- Hemoglobin S
- HGBE
- HGBN-A1
- HGBN-A2
- HGBN-C
- HGBN-F
- HGBN-S
- HGB-EVAL
- INTRPCHG
- HGBN Interpretation Charge
- HGBCM
Specimen Requirements
Collect specimen in a lavender top (EDTA) tube. Invert specimen after collection to prevent clotting. Send intact specimen; do not centrifuge. Refrigerate; do not freeze. Must include most recent CBC results (performed within 5 days of HGBE specimen collection).
Additional Information
Testing includes Hemoglobins A1, A2, C, F and S. By ordering this test, the clinician acknowledges that a pathologist interpretation will be performed and billed as a separate charge if indicated. Confirmation of all new cases of hemoglobin variants and homozygous sickle samples will be performed in-house by capillary electrophoresis or by an outside reference laboratory at an additional charge. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. All confirmation testing will be performed on test systems different from initial test system, as per CAP requirements. Various sendout confirmation test sites may be utilized depending on the complexity or uniqueness of the hemoglobinopathy. Confirmation tests may include pathologist interpretation of results at an additional charge.