Test Overview
Sequence Specific Oligonucleotide Polymorphism (SSOP) and Next Generation Sequencing (NGS).
Hematopoietic Cell Transplant (HCT) recipients are typed for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQB1, -DQA1, -DPB1, -DPA1, loci by high resolution (allele level) molecular methods.
In addition to the HLA high resolution typing patients are screened for preformed anti-HLA antibodies, the detection of anti-HLA antibodies directed to possible mismatches in less ideal donors is related with delay in the platelets and neutrophil engraftment and even with graft rejection.
Interpretive report provided.
* Reference ranges may change over time. Please refer to the original patient report when evaluating results.
Test Details
5 days
- Bone Marrow Transplant Recipient
- HLA Class I High Resolution
- HLA High Resolution Typing
- HLA Antibody Screen Mixed
- HLA Screening Class I & II
- HLA Class II High Resolution
Specimen Requirements
Collect specimens in sufficient yellow top (ACD) solution A tube AND SST tubes. Send intact specimens at room temperature. Do not refrigerate or freeze.
HLAAB: 10 mL Red Top or SST tube
HLAAB: 3 mL Red top or SST tube
Specimens that are not properly labeled with 2 identifiers will be rejected.
Insufficient sample amounts will be rejected.
Additional Information
Test includes HLA Typing Class I & II and Antibody Screening Class I & II. HLA Antibody Specificity Class I and II will be performed if indicated. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated.
HLA Typing should only be ordered once every five years.